Aripiprazole CAS NO.129722-12-9

Aripiprazole is a new type of high lipid solubility quinoline ketone derivatives, thepharmacological characteristics is postsynaptic dopamine D 2 receptor antagonist, is presynaptic dopamine D 2 receptor agonists. There are alsoexcited D 1, D for 3, D 4 receptor; has a dual role of partial receptor antagonistor activation of 5-HT 1A receptors have completely antagonistic to 5-HT; the role of the 2A receptor. This characteristic is different from the first generation and atypical antipsychotic drugs, namely the second generation antipsychotic drug,so called dopamine system stabilizer or third generation antipsychotic drug. Sincethe world, mainly used in the clinical treatment of schizophrenia, schizoaffective psychosis and other psychiatric disorders. According to the literature,aripiprazole and clozapine in treatment of schizophrenia with positive andnegative symptoms and anxiety, depression, cognitive function and has obvious curative effect, and higher safety 1. There are also people who reported the treatment of other mental disorders can be the drug also, such as affective disorder manic episodes, psychiatric disorders, dementia and senile anxiety disorder, child behavior disorders, such as depression.

Purity: Assay no less than 99.0%;

Appearance: White Crystalline Powder;

Molecular Formula: C23H27Cl2N3O2;

Molecular Weight: 448.385

Synonyms: 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one;Abilify;Aripiprex.

Storage Comdition: 20°C-30℃ 

Name:	Aripiprazole
CAS No.:	129722-12-9
Molecular Structure:
Formula:	C23H27Cl2N3O2
Molecular Weight:	448.39
Synonyms:	Aripiprazole [USAN];Aripiprazole (JAN/USAN);2(1H)-Quinolinone,7-[4-[4-(2,3-dichlorophenyl)- 1-piperazinyl]butoxy]-3,4-dihydro-;7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone;Abilitat;7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone;OPC-14597;Abilify (TN);Abilify;7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one;OPC 31;2(1H)-Quinolinone, 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-;Opc 14597;Arpiprazole;Alipiprazole;Aripiprzole;Aripipazole;7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one;
EINECS:
Density:	1.263 g/cm3
Melting Point:	139 °C
Boiling Point:	646.2 °C at 760 mmHg
Flash Point:	344.6 °C
Solubility:
Appearance:	colourless flake crystalline solid

Description: Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.